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In Vitro Maturation Of Oocytes ( IVM )

In certain conditions like polycystic ovaries or poor responders, in spite of ovarian stimulation follicular response from the ovaries might be poor.

It may be necessary to abandon the cycle and try a different stimulation protocol in another cycle. It is never certain that we will get a good response in the second cycle. In polycystic ovaries the risk of ovarian hyper stimulation syndrome (OHSS) could be virtually avoided.

Now, we have the technology to aspirate the ovarian follicles at 5-10mm or smaller, instead of waiting for the follicles to grow to 18mm in size. After collecting these immature eggs (germinal vesicles) we can grow them in the laboratory under special culture conditions. However, at present not more than 70% of the immature eggs reach maturity in our laboratory. The eggs which have reached maturity are subjected to sperm microinjection by ICSI.

The fertilization of the eggs is around 70%. The eggs that are fertilized (embryos) are transferred in the same way as embryos from routine IVF. If there are any surplus embryos that are good quality they are cryopreserved for future use.

This is a big advance in our laboratory technology, thanks to our scientists. The first baby that is born by this method is now 10 years old from an Indian couple in our centre abroad. The first baby from IVM at Miracle is now just over two years old. This technology is also used when the ovarian response is very slow even after ten days stimulation. We think a day will come when we may not have to give ovarian stimulation at all and aspirated immature eggs from the ovarian follicles, mature them in the laboratory, fertilize them and transfer the embryos. This will reduce the cost of infertility treatment and also shorten the number of days the couple have to attend the centre. We feel this treatment can also be used in women who respond poorly to high dose stimulation and produce one of two follicles.

Please discuss this with your doctor.